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monitoring documenting hypoglycemia followed by hyperglycemia still does not indicate if the hyperglycemia is due to inadequate insulin concentrations to prevent hyperglycemia. This requires concurrent measurement of circulating insulin concentrations.
In summary, in humans, the frequent occurrence of
the Somogyi effect has been refuted, and in a study of glargine-treated diabetic cats, blood glucose curves consistent with insulin-induced rebound hyperglycemia were very rare, despite the frequent occurrence of biochemical hypoglycemia. It is important to recognize that the  uctuations of blood glucose concentration occur commonly in the  rst weeks, and more rarely months, following the initiation of treatment with glargine, and can be mistaken for the Somogyi effect. However these  uctuations generally resolve with time using consistent dosing.
As a rule of thumb for clinicians, the dose of glargine
or detemir should be reduced if the cat develops asymptomatic or clinical hypoglycemia, but not
when blood glucose concentration is high and poorly responsive to insulin. In cats with intermediate acting insulin and experiencing hyperglycemia, with or without preceding hypoglycaemia, it is strongly recommend that the cat be switched to a longer acting insulin. When this is not possible, consider increasing the frequency of dosing. Insulin dose should be reduced if hypoglycaemia occurs, especially if it results in clinical signs.
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10 Choudhary P, Davies C, Emery CJ, et al. Do high fasting glucose levels suggest nocturnal hypoglycaemia? The Somogyi effect-more  ction than fact? Diabet Med. 2013; 30: 914-7.
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13. Roomp K, Rand J. Rebound Hyperglycemia In Diabetic Cats J Feline Med Surg. 2016 Aug;18(8):587-96. doi: 10.1177/1098612X15588967
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