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On the horizon
The future medical management of canine OSA will likely involve novel molecular or immunotherapies, as well as monitoring tools such as molecular biomarkers, molecular diagnostic techniques, molecular imaging (PET-CT, PET-MRI).
Concensus guidelines for conveying clinical trials as well as standardized diagnostic work up and management of human osteosarcoma have been published by severeal groups and could act as inspiration for future veterinary osteosarcoma guidelines.
Selected references
Szewczyk M, Lechowski R, et al. What do we know about canine osteosarcoma treatment? Review. Vet Res Commun. 2015 Mar;39(1):61-7
Wycislo KL, Fan TM. The immunotherapy of canine osteosarcoma: a historical and systematic review. J Vet Intern Med. 2015 May-Jun;29(3):759-69.
Mason NJ, Gnanandarajah JS, Engiles JB, Gray F, Laughlin D, Gaurnier-Hausser A, et al. Immunotherapy with a HER2-Targeting listeria induces HER2-Specific immunity and demonstrates potential therapeutic effects in a phase I trial in canine osteosarcoma. Clin Cancer Res. 2016;22(17):4380–90.
Quek R, Farid M, Chan LP, Chin FKC, Foo L, Lee VKM, et al. Singapore cancer network (SCAN) guidelines for the initial evaluation, diagnosis and management of retroperitoneal soft tissue sarcoma. Ann Acad Med Singapore. 2015;44(10):484– 91.
Reed DR, Hayashi M, Wagner L, Binitie O, Steppan DA, Brohl AS, et al. Treatment pathway of bone sarcoma in children, adolescents, and young adults. Vol. 123, Cancer. 2017. p. 2206–18.
Stuttgart K, Group O, Alto P, Group SS, Salter L, Hospital PC, et al. EURAMOS-1, an international randomised study for osteosarcoma: results from pre- randomisation treatment. ANNONC-2014-1266 Running header: EURAMOS-1 international randomised study for osteosarcoma Article type: Original article Versi. 2014;1–29.
Falk S, Dickenson AH. Pain and Nociception: Mechanisms of Cancer-Induced Bone Pain. J Clin Oncol. 32:1647–54.
Ramirez III O, Dodge RK, Page RL, Price GS, Hauck ML, LaDue T a, et al. Palliative radiotherapy of appendicular osteosarcoma in 95 dogs. Vet Radiol Ultrasound [Internet]. 1999;40(4):517–22.
Barger A, Graca R, Bailey K, Messick J, de Lorimier L-P, Fan T, et al. Use of alkaline phosphatase staining to differentiate canine osteosarcoma from other vimentin-positive tumors. Vet Pathol; 2005; 42(2):161–5.
An Urban Experience

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