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An Urban Experience
in feline OS was almost half the number of mitoses in canine OS.
Mean metastatic rate was 10%, and 44% of feline
OS had local recurrence. Recurrence frequency was influenced by marginal excision and the high number of axial and EOS.
Among the clinical variables that were evaluated as prognostic indicators using multivariate analysis, only complete surgical resection had a significant effect
on ST, DFI, and RFI. Although the recurrence rate in feline OS appears to be high (44%) according to our study, cats that had surgery had increased ST and
time to recurrence compared with animals that had no resection at all. It is possible that surgery in combination with adjunctive chemotherapy can further prolong ST and recurrence-free periods for feline OS. Although some case reports of feline OS treated with surgery
and adjunctive chemotherapy have shown long ST and recurrence-free periods, there are currently no blinded studies that evaluate the role of chemotherapy and radiation in the management of feline OS.2
In conclusion, feline OS has variation in histologic appearance that is not related to tumor localization. Histologic characteristics of feline OS are similar to those observed in canine skeletal OS. Histologic grade and mitotic index seem to be the most important prognostic factors for survival.
1Helm J, Morris J. Musculoskeletal neoplasia: an important differential for lumps or lameness in the cat. J Feline Med Surg. 2012 Jan;14(1):43-54.
2Dimopoulou M, Kirpensteijn J, Moens H, Kik M. Histologic prognosticators in feline osteosarcoma:
a comparison with phenotypically similar canineosteosarcoma. Vet Surg. 2008 Jul;37(5):466-71

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