Page 524 - ONLINE PROCEEDING BOOK WSAVA 2017
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An Urban Experience
WSVA7-0333
INFECTIOUS DISEASES I
CANINE AND FELINE RELAPSING FEVER BORRELIOSIS
G. Baneth1
1Hebrew University of Jerusalem, Koret School of Veterinary Medicine, Rehovot, Israel
CANINE AND FELINE RELAPSING FEVER BORRELIOSIS
Gad Baneth, DVM, PhD. Dipl. ECVCP
Koret School of Veterinary Medicine, Hebrew University, Rehovot 76100, Israel
Email: gad.baneth@mail.huji.ac.il
Relapsing fever (RF) is an infectious disease caused by arthropod-borne spirochetes of the genus Borrelia (1). The disease is characterized by recurrent episodes of fever borrelemia (2). The RF borrelioses include louse- borne RF caused by Borrelia recurrentis and tick-borne endemic RF transmitted by argasid soft ticks and caused by several Borrelia spp. such as Borrelia crocidurae, Borrelia coriaceae, Borrelia duttoni, Borrelia hermsii, Borrelia hispanica and Borrelia persica. Human
infection with B. persica is transmitted by the soft tick Ornithodoros tholozani and has been reported from Iran, Israel, Egypt, India, and Central Asia (2). Dogs have been reported to be infected with B. crocidurae, B. hermsii and B. persica while no report of feline RF borreliosis has been published before (3-7).
During 2003-2015,  ve cats and  ve dogs from Israel were presented for veterinary care and detected with the presence of Borrelia sp. in blood by observation of blood smear microscopy. The causative infective agent in these animals was identi ed as B. persica and characterized by PCR from blood and sequencing of parts of the  agellin ( ab), 16S rRNA and glycerophosphodiester phosphodiestrase (GlpQ) genes. All animals were infected with B. persica genetically identical to the causative agent of human RF. Phylogenetic analysis indicated that DNA sequences from these cats and
dogs clustered together with B. persica genotypes I
and II from humans and O. tholozani ticks and distinctly from other RF Borrelia spp. The main clinical  ndings
in cats included lethargy, anorexia, anemia in 5/5 cats and thrombocytopenia in 4/5. All dogs were lethargic and anorectic, 4/5 were febrile and anemic and 3/5
were thrombocytopenic. Three dogs were co-infected with Babesia spp. The animals were all treated with antibiotics and the survival rate of both dogs and cats was 80%. The cat and dog that succumbed to disease died one day after the initiation of antibiotic treatment,
while survival in the others was followed by the rapid disappearance of spirochetemia.
This is the  rst report of disease due to B. persica infection in cats and the  rst case series in
dogs. Infection was associated with anemia and thrombocytopenia. Fever was more frequently observed in dogs than cats. Domestic canines and felines suffer from clinical disease due to B. persica infection and may also serve as sentinels for human infection.
References
1. Parola P, Raoult D. Ticks and tickborne bacterial diseases in humans: an emerging infectious threat. Clin Infect Dis. 2001;32:897-928.
2. Assous MV, Wilamowski A. Relapsing fever borreliosis in Eurasia--forgotten, but certainly not gone! Clin Microbiol Infect. 2009;15:407-14.
3. Breitschwerdt EB, Nicholson WL, Kiehl AR, Steers C, Meuten DJ, Levine JF. Natural infections with Borrelia spirochetes in two dogs from Florida. J Clin Microbiol. 1994;32:352-7.
4. Whitney MS, Schwan TG, Sultemeier KB, McDonald PS, Brillhart MN. Spirochetemia caused by Borrelia turicatae infection in 3 dogs in Texas. Vet Clin Pathol. 2007;36:212-6.
5. Kelly AL, Raffel SJ, Fischer RJ, Bellinghausen M, Stevenson C, Schwan TG. First isolation of the relapsing fever spirochete, Borrelia hermsii, from a domestic dog. Ticks Tick Borne Dis. 2014;5:95-9.
6. Shirani D, Rakhshanpoor A, Cutler SJ, Ghazinezhad B, Naddaf SR. A case of canine borreliosis in Iran caused by Borrelia persica. Ticks Tick Borne Dis. 2016. pii: S1877-959X(15)30061-3.
7. Baneth G, Nachum-Biala Y, Halperin T, Hershko Y, Kleinerman G, Anug Y, Abdeen Z, Lavy E, Aroch I, Straubinger RK. Borrelia persica infection in dogs and cats: clinical manifestations, clinicopathological  ndings and genetic characterization. Parasit Vectors. 2016 May 10;9(1):244.
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42ND WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND FECAVA 23RD EUROCONGRESS


































































































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