Page 680 - ONLINE PROCEEDING BOOK WSAVA 2017
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680
An Urban Experience
dominant early-age cataracts in the Australian Shepard breed. There are many documented breed-related inherited cataracts, and some breeds have more than one inherited cataract; differentiated by age of onset, progression and lens location. Other causative mutations have not yet been discovered.
Other Common Genetic Disorders
Other common disorders include; non-struvite bladder stones, elbow dysplasia, hepatic shunts, epilepsy, glaucoma, deafness, blindness, renal dysplasia and Addison’s disease. Common Mendelian disorders with genetic tests include; the prcd form of progressive retinal atrophy, mdr1-related drug sensitivity, arrythmogenic right ventricular cardiomyopathy in Boxers and Boxer crosses, von Willebrand’s disease and a liability gene for degenerative myelopathy.
Conclusion
The WSAVA Canine and Feline Hereditary Disease (DNA) Testing website (http://research.vet.upenn.edu/WSAVA- LabSearch) is an excellent source for DNA tests, lists of susceptible breeds and testing laboratories.
Dogs affected by genetic disorders should not be selected for breeding. Because most of these genetic diseases are complexly inherited, genetic risk for carrying disease-liability genes should be based on knowledge
of clinical disease or normalcy in  rst-degree relatives
of prospective breeding dogs. This can be facilitated through on-line health registry databases. Carriers of testable recessive disease-liability genes can be bred with normal-testing mates and replaced for breeding with normal-testing offspring. Dogs with testable dominant disease-liability genes should be replaced for breeding with normal-testing relatives.
42ND WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND FECAVA 23RD EUROCONGRESS


































































































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