Page 706 - ONLINE PROCEEDING BOOK WSAVA 2017
P. 706

An Urban Experience
Fig 1. Pheochromocytoma
Fig 2. Left ventricular hypertrophy
WSVA7-0092
CARDIO-RESPIRATORY MEDICINE AND SURGERY
EVALUATION OF RIGHT VENTRICULAR SYSTOLIC FUNCTION IN DOGS WITH CHRONIC MITRAL VALVE DISEASE
L.C. Petrus1, M.H.M.A. Larsson2, A.M. Gimenes1, J.R. Castro1, M. Mantovani1, C.N. Duarte1,
P.H. Itikawa3, G.T. Goldfeder1, D.S. Schwartz1
1Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo, Clínica Médica, São Paulo, Brazil
2Faculdade de Medicina Veterinária e Zotecnia da Universidade de São Paulo, Clínica Médica, São Paulo, Brazil
3Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo, Clínica Medica, São Paulo, Brazil
Introduction
The most frequent cause of pulmonary arterial hypertension (PAH) in the dog is chronic mitral valve disease (CMVD).
Objectives
To identify echocardiographic changes in right ventricle (RV) systolic function at different stages of CMVD and,
if tricuspid insuf ciency (TI) is present, to correlate with the TI velocity. Our hypothesis is that RV systolic function decreases with severity of CMVD, and that it is correlated with PAH estimated by TI velocity.
Methods
Ninety six dogs were grouped according to CMVD severity based on thoracic radiographs, echocardiographic evaluation and clinical signs. The dogs were equally distributed in each group: A, B1, B2 and C, according to American College of Veterinary Internal Medicine staging system. Indicators of RV systolic function were tricuspid annular plane systolic excursion indexed to body surface area (iTAPSE), fractional area change [FAC=(RV max area - RV min area)/ RV max area] and S´ wave velocity of RV posterior wall. All parameters were obtained by modi ed left apical four chamber view. TI was detected by colour Doppler and its velocity was measured by continuous Doppler echocardiography.
Results
iTAPSE was higher in stage C than control (p=0.001); FAC was higher in stage C than stage B2 (p<0.0001); S´ wave velocity did not differ between the groups (p= 0.774). TI was detected in thirty-two animals (33.3 %), and no statistical signi cant correlation was detected to RV systolic function.
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Microscopically the tumor was a pheochromocytoma,
as con rmed by immunohistochemisrty with antibodies against synaptophysin. Microscopic examination
of the heart revealed multifocal area of mild  brosis accompanied by in ammatory in ltration with predominating small lymphocytes. Multifocal hypertrophy of cardiomyocytes characterized by the presence
of enlarged vesicular nuclei with visible nucleoli and abundant sarcoplasm was also observed. In some of these cells brown granules of lipofuscin were also present.
Conclusions
This is a rare case of LV hypertrophy in dogs caused by a pheochromocytoma and systemic hypertension.
42ND WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND FECAVA 23RD EUROCONGRESS


































































































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