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An Urban Experience
 WSVA7-0130
(CLINICAL) PATHOLOGY
UNCOMMON CHRONIC MULTIFOCAL DISTEMPER ENCEPHALOMYELITIS IN TWO MATURE DOGS
Y. Abou Mounsef1, S. Atalay Vural1, P. Can2, O. Besalti2
1Ankara University Veterinary Faculty, Pathology, Ankara, Turkey
2Ankara University Veterinary Faculty, Surgery, Ankara, Turkey
Introduction
Canine distemper virus (CDV) is a highly contagious, systemic, viral disease that commonly causes central nervous system disease in immature dogs. CDV
can produce an unusual form of encephalomyelitis known as ‘multifocal distemper encephalomyelitis in mature dogs’. This chronic progressive form is a rare manifestation of CDV.
Objectives
The aim of the report is to highlight the clinicopathological findings of two spontaneous cases of multifocal distemper encephalomyelitis in mature dogs and to show the pathological differences between this form and the usual CDV form in immature dogs.
Methods
Three years old English setter and 10 years old German pointer dogs were referred to clinics with 10 days history of generalized twitching and trembling. Dogs developed the signs suddenly after they went on the same hunting trip with their owners. The dogs were euthanized and their necropsies were performed. Tissue samples were routinely processed and stained with Haematoxylin
& Eosin (H&E) and Luxol Fast blue(L.F.B.) methods. Immunohistochemical analysis was carried out, using CDV antibody.
Results
Histologically, severe non purulent meningoencephalomyelitis was seen (figure1) and few acidophilic intranuclear inclusion bodies were found located specially within astrocytic nuclei (figure2). Those lesions were more prevalent in the hippocampus,
the brain stem, cerebellum and the spinal cord.
Conclusions
Despite extensive vaccination of dogs against CDV, recent reports shows re-emergence and increased activity of CDV worldwide. Our report proves that CDV should be considered in the differential diagnosis of neurologic diseases of mature dogs even if they were vaccinated.
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 42ND WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND FECAVA 23RD EUROCONGRESS
  












































































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