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WSVA7-0139 GASTROENTEROLOGY
WHITE BILE SYNDROME IN A DACHSHUND
V. Ceplecha1, K. Rehakova2, P. Proks3, G.C.M. Grinwis4, M. Vavra1, M. Crha1
1University of Veterinary and Pharmaceutical Sciences Brno, Small Animal Clinic, Brno, Czech Republic 2University of Veterinary and Pharmaceutical Sciences Brno, Small Animal Clinical Laboratory, Brno, Czech Republic
3University of Veterinary and Pharmaceutical Sciences Brno, Department of Diagnostic Imaging, Brno, Czech Republic
4Utrecht University, Department of Pathobiology, Utrecht, The Netherlands
Introduction
White bile syndrome is characterised by colourless viscid bile accumulation in the gall bladder and/or bile ducts. In human medicine this syndrome has been described as
a consequence of extrahepatic biliary duct obstruction (EHBDO) associated with resorption of bile pigments. To the author’s knowledge the colourless viscid  uid in the gall bladder has not been previously documented in dogs.
Objectives
Here we describe this rare phenomenon in a 7 years old spayed female dachshund presented for icterus of 7 weeks duration and acholic faeces.
Methods
Serum biochemistry revealed hyperbilirubinemia with marked increase in ALT, ALP, AST and GGT suggesting cholestatic hepatobiliary disease. Because of severe gall bladder changes during abdominal ultrasound,
a laparotomy with cholecystectomy and wedge liver biopsy were performed. No obvious cause of obstruction was found. Bile obtained via cholecystocentesis was atypically colourless and viscid.
Results
Cytology of the gall bladder contents revealed moderate purulent in ammation with a massive population of predominantly rod-shaped bacteria, occasionally phagocytized. Bile culture showed con uent growth of E. coli (++++). Histopathology found moderate to marked granulomatous hepatitis and chronic lymphoplasmacytic cholecystitis with cholelithiasis. The dog was treated with antibiotics (amoxicillin/clavulanic acid, metronidazole
and enro oxacin) in order to eliminate E. coli infection and supportive drugs (S-adenosylmethionine, silymarin, ursodiol, famotidine).
42ND WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND FECAVA 23RD EUROCONGRESS
An Urban Experience
cirrhosis were 100 % and 90.8 %, respectively. TGF-β1 levels did not signi cantly differ among groups. Statistical signi cance was set at p < 0.05.
Conclusions
The present results suggest that increased serum HA concentration is a potential noninvasive marker for canine liver cirrhosis.
Acknowledgment
Financial support was provided by IGA VFU Brno 129/2016/FVL.


































































































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