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WSVA7-0181 NEUROLOGY/NEUROSURGERY
ACUTE CANINE LOWER MOTOR NEURON DISEASE: IS IT ALWAYS POLYRADICULONEURITIS?
T. Liatis1, O. Baka1, K. Matiasek2, M. Rosati2, A. Danourdis3, Z. Polizopoulou4
Results
Treatment consisted of physiotherapy (5/5), intensive care and mechanical ventilation (1/5), gabapentin (1/5), clindamycin (2/5), prednisolone (1/5). One dog died
of respiratory paralysis, one was euthanased, while 2 remained stable and one improved during follow up.
Conclusions
Polyneuropathies should be differentiated by myopathies and junctionopathies or focal myelopathies. Wet muscle biopsy allows for assessment of myofibre enzyme activities, muscle fibrils, mitochondria, denervation atrophy and pathological storage of polysaccharides and lipids. Nevertheless, the gold standard for diagnosing polyneuropathies is nerve biopsy.
An Urban Experience
  1Aristotle University of Thessaloniki, Unit of Medicine- Companion Animal Clinic- School of Veterinary Medicine- Faculty of Health Sciences, Thessaloniki, Greece 2Ludwig Maximilian University of Munich, Clinical & Comparative Neuropathology Laboratory- Institute
of Veterinary Pathology- Centre for Clinical Veterinary Medicine- Faculty of Veterinary Medicine, Munich, Germany
3Freelancer, Vet Hospital, Halandri, Greece
4Aristotle University of Thessaloniki, Diagnostic Laboratory- School of Veterinary Medicine- Faculty of Health Sciences, Thessaloniki, Greece
Introduction
Polyneuropathies are multifactorial disorders, frequently encountered in practice, characterized by lower motor tetraparesis/-plegia with or without cranial nerve deficits.
Objectives
This report presents the diagnostic investigation of 5 canine polyneuropathy cases, selected out of a 16-caseload (2016).
Methods
Five male dogs were presented with flaccid tetraparesis (2/5), tetraplegia (2/5) or abnormal gait (1/5). Onset
of signs was acute (4/5) or subacute (1/5). Dysphonia (3/5) and dysphagia (1/5) were also noted. Neurologic examination revealed generalized weakness (4/5), flaccid tetraparesis (2/5) and tetraplegia (2/5), carpal laxity (1/5), depression (1/5), generalized (2/3) or localized (1/3) muscle atrophy. Proprioception deficits (2/5), hyporeflexia (4/5) and laryngeal paresis (1/5) were noted. Anti-acetylcholine receptor antibody titer (2/2), thyroid function testing (2/2) and cerebrospinal fluid analysis (2/2) were normal. Serology for Toxoplasma gondii IgM (1/1) and snap test for Leishmania infantum (2/3) were negative. Electromyography revealed diffuse spontaneous electrical activity (4/4). Wet biopsy of muscle (cryohistology) revealed chronic denervation muscle atrophy (5/5), lymphoplasmacytic (1/5) or lymphohistiocytic (1/5) chronic interstitial myositis, chronic axonal neuropathy (1/5) or diffuse lympho- plasmacytic neuritis/perineuritis (1/5).
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