Page 760 - WSAVA2017
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An Urban Experience
Results
Although several dogs experienced temporal and mild pyrexia, any other significant adverse events were
not detected during and after injection of rcIL-15. Administration of rcIL-15 in combination with metronomic cyclophosphamide remarkably increased the number of NK cells and its anti-cancer activities, and significantly decreased the number of regulatory T cells in the peripheral blood of all patients, which were associated with improved clinical outcomes.
Conclusions
Our results suggest rcIL-15 is safe and has tremendous potential for antitumor therapy for dogs.
WSVA7-0178 ONCOLOGY/ONCOSURGERY
CHRONIC PAPILLOMATOSIS ASSOCIATED TO SCC IN DOGS: A CASE REPORT
O. Borges1, L. Medeiros1, L. Silva1, R. Ximenes1, T. Lima1, A. Dantas1, R. Silva1, A. Souza1
1Universidade Federal de Campina Grande, Unidade Acadêmica de Medicina Veterinária, Patos, Brazil
Introduction
Genetic predisposition and chronic exposure to risk factors benefit the development of tumors in dogs,
and with the skin being the most affected organ, it is possible to highlight the Squamous Cells Carcinoma (SCC). However it is not normally described for dogs, the association between papillomavirus and SCC has already been done in large animals.
Objectives
Describe a case of chronic papillomatosis associated
to cutaneous SCC in a dog, also describing clinical and epidemiological findings, emphasizing the papillomavirus as risk factor.
Methods
A dog, five years old was attended to a veterinary
facility with complaints that for the last six months it
has been presenting prepuce ulceration and small
warty nodules on the face and abdomen skin, later
being diagnosed with cutaneous papillomatosis. It
was treated for two months with no significant clinical improvement. The lesions evolved to bigger, elastic-firm, alopecic, papilliform, hyperkeratotic, brownish to pinkish nodulesspread out on abdominal, inguinal and facial regions with higher intensity in the oral cavity and tongue. It was requested cytology of the face warts as well as histopathology and immunohistochemistry of abdominal and inguinal regions warts.
Results
The cytological test suggested cutaneous papillomatosis. In the histopathological analysis it was found well differentiated SCC. The immunohistochemistry showed positive immuno-mark for papillomavirus.
Conclusions
In clinical cases with possible chronic cutaneous papillomatosis, it should always be carried out complementary adequate tests and techniques, considering SCC as the main differential diagnosis. Papillomavirus is deeply associated to neoplastic lesions characterized as SCC.
   42ND WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND FECAVA 23RD EUROCONGRESS
  





































































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