Page 765 - ONLINE PROCEEDING BOOK WSAVA 2017
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WSVA7-0204 OPHTHALMOLOGY
A CASE REPORT OF CORNEAL WOUND IN DOMESTIC SHORT HAIR CAT TREATED WITH N-ACETYLCYSTEINE AND AUTOLOGOUS SERUM
S. Ghadirian1, M. Rezaei2
1Kara Pet Clinic, Small Animal Clinic, Tehran, Iran 2Vet Clinic, Komijan, Markazi, Iran
Introduction
A 5 months-old Domestic Short Hair cat with bilateral deep corneal wounds was presented to our Pet Clinic. After a week local antibiotics therapy decided to do corneal keratotomy. Post operative therapy included topical antibiotics and analgesics. To achieve better results used N-Acetylcysteine and autologous serum individually.
Objectives
Corneal ulceration is a common problem in cats. N-Acetylcysteine has been used in ophthalmology to treat corneal diseases. Autologous serum can be used in most ulcerate keratitis, too. Although we can not  nd any comparative studies of the effects of N-AC compared with autologous serum on ulcerate corneal healing in cats.
Methods
This cat with bilateral deep corneal ulcers treated topically on right eye with one drop of N-Acetylcysteine 2% and on the left eye used one drop of autologous serum every 2 hours. These drops reduced to every 4 hours after  rst week. Corneal ulcers were measured by  uorescein staining every 2 days to determine the extent of progression in 30 days treatment period.
WSVA7-0078 OPHTHALMOLOGY
THE EFFECT OF PRE-ANESTHESIA WITH COMBINATION OF KETAMINE-MIDAZOLAM ON INTRAOCULAR PRESSURE IN NORMAL FELINE EYES
S.M. Rajaei1, F. Asadi2, R. Mohammad Reza3, M. Ansari mood4
1Islamic Azad University- Karaj Branch, Department of Clinical Sciences, Karaj, Iran
2University of Semnan, Faculty of Veterinary Medicine, Semnan, Iran
3University of Tehran, Faculty of Veterinary Medicine, Tehran, Iran
4Islamic Azad University- Science and Research Branch, Department of clinical sciences, Tehran, Iran
Introduction
The incidence of glaucoma in cats is less than dogs, but it is important to maintain IOP within normal reference values during and after the surgery
Objectives
To assess the effect of intramuscular Ketamine– Midazolam administration on IOP in normal feline eyes
Methods
Fifteen adult domestic short-haired cats ranging in
age from 14-20 months were used for this study. The treatment group (n=8) received intramuscular (IM) Ketamine 10 Mg/kg in combination with midazolam 0.1 Mg/kg and distilled water was injected IM for the control group (n=7). Baseline IOP was measured by using rebound tonometer. Then at the time of 10, 20, 30, 45, 60, 90, 120 minutes, and 24 hours after administration, the IOP of all eyes in both groups measured
Results
The baseline Mean±SD IOP values in treatment and control groups were 19.57±3.32 mmHg and 17.35±1.86 mmHg, respectively. In the treatment group mean IOP increased at T10, T45, and T60 after drug administration but this increase was not statistically signi cant (P>0.13). In the control group IOP did not change except a mild decrease at T10 (P>0.11). A comparison between the two groups, revealed that IOP signi cantly altered at T10, T45, T60, T90 and T120. There was no signi cant difference between control and treatment group at baseline and 24 hours after drug administration
Conclusions
Intramuscular administration of Ketamine-midazolam combination as a pre-anesthetic did not increased IOP signi cantly in clinically healthy cats
Results
Both N-Acetylcysteine and autologous serum were signi cantly decrease healing time. Clinical examination 30 days after operation showed that corneal haze were lesser in treated eyes compared to the imagination. Consequently the result of this experiment showed that topical autologous serum and N-AC can be useful in treatment of corneal ulcers.
Conclusions
Eye drops made from autologous serum or N-AC have
a tear like biochemical character and supply nutritional components. This drop supports viability, proliferation and migration of ocular surface epithelial cells better than unpressed pharmaceutical tear.
An Urban Experience
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