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An Urban Experience
WSVA7-0207 REPRODUCTION, PEDIATRICS
PRELIMINARY RESULTS ON THE EFFECTS OF GESTATIONAL AGE AND FETUSES NUMBER ON CARDIAC FUNCTION IN GREAT DANE BITCHES
M. Melandri1, I. Spalla2, L. Fanciullo3, S. Alonge1
1Ambulatorio Veterinario “Il Melograno”, Obstetrics & Gynecology, SESTO CALENDE VA, Italy
2Royal Veterinary College, Cardiology, London, United Kingdom
3Ambulatorio Veterinario “Il Melograno”, Cardiology, SESTO CALENDE VA, Italy
Introduction
Pregnancy is associated with changes in cardiac function (1) to support fetal development (2); few studies analyzed factors affecting this adaptation. Gestational cardiac changes assessment could elucidate cardiac adaptation process to large pregnancies for the expected greater circulating volume increase.
Objectives
To evaluate the effects of gestational age and fetuses number on maternal cardiac function.
Methods
Nine healthy Great Dane bitches underwent standard M-mode and B-mode echocardiographic exam prior to (T0), 21-days (T1) after ovulation and within 7 days of predicted parturition (T2). After whelping, bitches were divided in 2 groups: small (<7 puppies) and large litters (>7 puppies). The effects of gestational age and fetuses number on end-point-septal-separation (EPSS), left atrial to aortic root ratio (LA/Ao), sphericity index (SI), stroke volume (SV), heart rate (HR) and cardiac output (CO) were evaluated by ANOVA. The SV, CO and HR variation between groups at T2 vs T0 was calculated.
Results
During pregnancy, SV, HR and CO significantly increased (p<0.01). In large pregnancies, SV, HR and CO resulted in greater increase at T2 by 10.8%, 10.5% and 11.47%, respectively. No statistical difference was observed for EPSS, LA/Ao and SI.
Conclusions
This study confirms that maternal heart undergoes significant changes along pregnancy. Moreover, it demonstrates that in large pregnancies there is a higher increase in SV, CO and HR that probably reflects the greater cardiovascular work to support fetal development. Further investigations would assess whether different changes occur during large litter pregnancies in different age and breed bitches.
1. Abbott J Vet Cardio 2010;12:123-8; 2.Blanco et al Theriogenology 2012;78:1235-4297.
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 42ND WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS AND FECAVA 23RD EUROCONGRESS
  














































































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