Page 83 - ONLINE PROCEEDING BOOK WSAVA 2017
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Differential diagnosis:
· Vitamin K de ciency e.g. rodenticides
· Hepatopathy
· DIC
· Angiostrongylus
· Drugs e.g. heparin, warfarin
· Inherited factor de ciencies
· VIII – Haemophilia A (German Shepherds, Cross breeds, Cats)
· IX – Haemophilia B (Various breed dogs, Cats)
· Others – I, II, VII, X, XI, XII Treatment:
· Fresh frozen plasma:
· 10 – 20 mL/kg
· Standardly over 4 hours, but can give quicker (over 30 minutes) if very critical patient
· Stored plasma
· 10 – 20 mL/kg
· No factor V or VIII, but vit K dependent factors present
· Fresh whole blood
· If anaemic as well as coagulopathic
· Stored whole blood
· If anaemic as well as coagulopathic due to vit K dependent factor de ciency
Hyper brinolysis
Diagnostic tests:
· Fibrin degradation products (FDP)
· Increase in DIC and hepatic disease
· Not very sensitive or speci c
· D-dimers
· Increase in recent (<5 hours) disease
· More sensitive and speci c than FDP
· Increase in DIC, thromboembolism, neoplasia, hepatic, renal failure, cardiac failure, recent haemorrhage
· Tissue plasminogen activated thromboelastography (needs to be inhouse)
Differential diagnosis:
· DIC
· Congenital in some Greyhounds (post-operative bruising may occur)
References are available upon request.
An Urban Experience
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